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. 2011 Jan;89(1):127-36.
doi: 10.1189/jlb.1009696. Epub 2010 Oct 19.

V体育官网 - Adenosine deaminase potentiates the generation of effector, memory, and regulatory CD4+ T cells

José M Martinez-Navio  1 , Víctor Casanova, Rodrigo Pacheco, Isaac Naval-Macabuhay, Núria Climent, Felipe Garcia, José M Gatell, Josefa Mallol, Teresa Gallart, Carme Lluis, Rafael Franco
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VSports - Adenosine deaminase potentiates the generation of effector, memory, and regulatory CD4+ T cells

José M Martinez-Navio et al. J Leukoc Biol. 2011 Jan.

Abstract

By interacting with CD26 on the CD4+ T cell surface and with the AdoR A(₂B) on the DC surface, ADA triggers a costimulatory signal for human T cells. The aim of this study was to know whether ADA-mediated costimulation plays a role in the differentiation of T cells VSports手机版. The results show that irrespective of its enzymatic activity and dependent on TNF-α, IFN-γ, and IL-6 action, ADA enhanced the differentiation of CD4+CD45RA+CD45RO⁻ naïve T cells toward CD4+CD25+CD45RO+ Teffs and CD4+CD45RA⁻CD45RO+ memory T cells. Furthermore, ADA potentiated generation of CD4+CD25(high)Foxp3+ Tregs by a mechanism that seems to be mainly dependent on the enzymatic activity of ADA. Interestingly, an ADA-mediated increase on Teff, memory T cell, and Treg generation occurred, not only in cocultures from healthy individuals but also from HIV-infected patients. These data suggest that ADA is a relevant modulator of CD4+ T cell differentiation, even in cells from immunologically compromised individuals. .

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