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. 2010 Aug 18;2(45):45ra59.
doi: 10.1126/scitranslmed.3001270.

VSports app下载 - The four-herb Chinese medicine PHY906 reduces chemotherapy-induced gastrointestinal toxicity

Wing Lam  1 , Scott Bussom, Fulan Guan, Zaoli Jiang, Wei Zhang, Elizabeth A Gullen, Shwu-Huey Liu, Yung-Chi Cheng
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The four-herb Chinese medicine PHY906 reduces chemotherapy-induced gastrointestinal toxicity

Wing Lam et al. Sci Transl Med. .

Abstract (V体育2025版)

PHY906, a four-herb Chinese medicine formula first described 1800 years ago, decreases gastrointestinal toxicity induced by the chemotherapeutic drug CPT-11 (irinotecan), as shown in a phase I/II clinical study. Similarly, in a murine colon 38 allograft model, PHY906 increased the antitumor activity of CPT-11 while decreasing animal weight loss caused by CPT-11. Here, we have further examined the effect of PHY906 on the intestinal toxicity caused by CPT-11 in mice VSports手机版. PHY906 did not protect against the initial DNA damage and apoptosis triggered by CPT-11 in the intestine, but by 4 days after CPT-11 treatment, PHY906 had restored the intestinal epithelium by promoting the regeneration of intestinal progenitor or stem cells and several Wnt signaling components. PHY906 also potentiated Wnt3a activity in human embryonic kidney-293 cells. Furthermore, PHY906 exhibited anti-inflammatory effects in mice by decreasing the infiltration of neutrophils or macrophages, tumor necrosis factor-alpha expression in the intestine, and proinflammatory cytokine concentrations in plasma. Chemical constituents of PHY906 potently inhibited nuclear factor kappaB, cyclooxygenase-2, and inducible nitric oxide synthase. Our results show that the herbal medicine PHY906 can counteract the toxicity of CPT-11 via several mechanisms that act simultaneously. .

Trial registration: ClinicalTrials V体育安卓版. gov NCT00730158. .

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