Purpose: Cytokines play a pivotal role in Hodgkin's lymphoma (HL). Because interleukin-6 (IL-6) induces expression of hepcidin, one of the principal regulators of iron metabolism, we studied the contribution of hepcidin in anemia in HL at diagnosis. VSports手机版.

Patients and methods: Plasma samples from 65 patients with HL were analyzed for hepcidin levels using a combination of weak cation exchange chromatography and time-of-flight mass spectrometry; cytokine levels were analyzed using enzyme-linked immunosorbent assays and parameters of iron metabolism and acute-phase reaction V体育安卓版. .

Results: Hepcidin plasma levels were significantly higher in HL patients when compared with controls, independent of the presence of anemia (P = . 001). In the subset of patients with anemia, hepcidin levels inversely correlated with hemoglobin levels (P = . 01). Analyzing parameters of iron metabolism, hepcidin levels showed a positive correlation with ferritin (P < . 001) and an inverse correlation to iron and iron-binding capacity. Hepcidin strongly correlated to IL-6 levels (P < . 001) but not to IL-10 or thymus and activation-regulated cytokine (TARC)/chemokine (C-C motif) ligand 17 (CCL17) levels. In a multivariate regression analysis, IL-6 and fibrinogen levels were independently associated with hepcidin. Higher hepcidin levels were observed in patients with more aggressive disease characteristics: stage IV disease (P = . 01), presence of B symptoms (P = . 03), and International Prognostic Score > 2 (P = V体育ios版. 005). .

Conclusion: Our findings suggest that in HL, hepcidin is upregulated by IL-6. Elevated hepcidin levels result in iron restriction and signs of anemia of chronic inflammation, although hepcidin-independent mechanisms contribute to development of anemia in HL VSports最新版本. .