Background & aims: Mechanisms underlying weight loss maintenance after gastric bypass are poorly understood VSports手机版. Our aim was to examine the effects of gastric bypass on energy expenditure in rats. .

Methods: Thirty diet-induced obese male Wistar rats underwent either gastric bypass (n = 14), sham-operation ad libitum fed (n = 8), or sham-operation body weight-matched (n = 8). Energy expenditure was measured in an open circuit calorimetry system. V体育安卓版.

Results: Twenty-four-hour energy expenditure was increased after gastric bypass (4. 50 +/- 0. 04 kcal/kg/h) compared with sham-operated, ad libitum fed (4. 29 +/- 0. 08 kcal/kg/h) and sham-operated, body weight-matched controls (3. 98 +/- 0. 10 kcal/kg/h, P < . 001). Gastric bypass rats showed higher energy expenditure during the light phase than sham-operated control groups (sham-operated, ad libitum fed: 3. 63 +/- 0. 04 kcal/kg/h vs sham-operated, body weight-matched: 3. 42 +/- 0. 05 kcal/kg/h vs bypass: 4. 12 +/- 0. 03 kcal/kg/h, P < . 001). Diet-induced thermogenesis was elevated after gastric bypass compared with sham-operated, body weight-matched controls 3 hours after a test meal (0. 41% +/- 1. 9% vs 10. 5% +/- 2. 0%, respectively, P < . 05). The small bowel of gastric bypass rats was 72. 1% heavier because of hypertrophy compared with sham-operated, ad libitum fed rats (P < . 0001) V体育ios版. .

Conclusions: Gastric bypass in rats prevented the decrease in energy expenditure after weight loss. Diet-induced thermogenesis was higher after gastric bypass compared with body weight-matched controls. Raised energy expenditure may be a mechanism explaining the physiologic basis of weight loss after gastric bypass VSports最新版本. .