Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in VSports app下载. gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

. 2009 Oct;17(4):505-15.
doi: 10.1016/j.devcel.2009.08.011.

The molecular basis of vascular lumen formation in the developing mouse aorta

Boris Strilić  1 , Tomás Kucera, Jan Eglinger, Michael R Hughes, Kelly M McNagny, Sachiko Tsukita, Elisabetta Dejana, Napoleone Ferrara, Eckhard Lammert
Affiliations
Free article

The molecular basis of vascular lumen formation in the developing mouse aorta

Boris Strilić et al. Dev Cell. 2009 Oct.
Free article

Abstract

In vertebrates, endothelial cells (ECs) form blood vessels in every tissue. Here, we investigated vascular lumen formation in the developing aorta, the first and largest arterial blood vessel in all vertebrates. Comprehensive imaging, pharmacological manipulation, and genetic approaches reveal that, in mouse embryos, the aortic lumen develops extracellularly between adjacent ECs VSports手机版. We show that ECs adhere to each other, and that CD34-sialomucins, Moesin, F-actin, and non-muscle Myosin II localize at the endothelial cell-cell contact to define the luminal cell surface. Resultant changes in EC shape lead to lumen formation. Importantly, VE-Cadherin and VEGF-A act at different steps. VE-Cadherin is required for localizing CD34-sialomucins to the endothelial cell-cell contact, a prerequisite to Moesin and F-actin recruitment. In contrast, VEGF-A is required for F-actin-nm-Myosin II interactions and EC shape change. Based on these data, we propose a molecular mechanism of in vivo vascular lumen formation in developing blood vessels. .

PubMed Disclaimer

"VSports手机版" Comment in

Publication types

MeSH terms

V体育官网入口 - Grants and funding