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. 1990 Oct 6;336(8719):850-4.
doi: 10.1016/0140-6736(90)92348-l.

European experience of bone-marrow transplantation for severe combined immunodeficiency

A Fischer  1 , P Landais, W Friedrich, G Morgan, B Gerritsen, A Fasth, F Porta, C Griscelli, S F Goldman, R Levinsky, et al.
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European experience of bone-marrow transplantation for severe combined immunodeficiency

A Fischer et al. Lancet. .

Abstract (VSports app下载)

The outcome of bone-marrow transplantations (BMT) carried out between 1968 and March 1, 1989, in 183 patients with severe combined immunodeficiency (SCID) was analysed. Recipients of HLA-identical BMTs (70) had a 76% probability of survival (median follow-up 73 months). Of the 32 treated since 1983, 97% have been cured (median follow-up 41 months). This good prognosis was associated with rapid development of T and B cell function VSports手机版. HLA-non-identical, T-cell-depleted, BMT (n = 100) gave significantly lower survival (52%; median follow-up 47 months). Factors associated with poor prognosis were the presence of a lung infection before BMT, absence of a protected environment, and use of female donors for male recipients. Use of a conditioning regimen significantly increased the frequency of sustained engraftment (86% vs 50% for non-conditioned BMT) and resulted in more frequent engraftment of donor B lymphocytes and myeloid cells. Donor B-cell chimerism was strongly associated with the development of normal B-cell function. .

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