Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The VSports app下载. gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure V体育官网. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. .

Comparative Study
. 2010 Jan;21(1):78-86.
doi: 10.1093/annonc/mdp280. Epub 2009 Jul 21.

V体育平台登录 - Genetic variations in angiogenesis pathway genes associated with clinical outcome in localized gastric adenocarcinoma

G Lurje  1 , H Husain, D G Power, D Yang, S Groshen, A Pohl, W Zhang, Y Ning, P C Manegold, A El-Khoueiry, S Iqbal, L H Tang, M A Shah, H-J Lenz
Affiliations
Comparative Study

Genetic variations in angiogenesis pathway genes associated with clinical outcome in localized gastric adenocarcinoma

G Lurje et al. Ann Oncol. 2010 Jan.

Abstract

Background: Angiogenesis has been attributed to be a well-recognized aspect of human cancer biology. As such, proteinase-activated receptor (PAR)-1, endostatin (ES) and interleukin-8 (IL-8) mediate the regulation of early-onset angiogenesis and in turn impact the process of tumor-growth and disease progression. VSports手机版.

Patients and methods: Formalin-fixed paraffin-embedded tissues were obtained from 137 patients with localized gastric cancer at University of Southern California and Memorial Sloan-Kettering Cancer Center medical facilities. DNA was extracted and genotyping was carried out using PCR-restriction fragment length polymorphism-based protocols V体育安卓版. .

Results: In false discovery rate-adjusted univariate analysis, PAR-1 -506 ins/del (P < 0. 001), ES +4349 G>A (P = 0. 004), and IL-8 -251 T>A (P < 0. 0001) were associated with time to tumor recurrence (TTR). Further, PAR-1 -506 ins/del and IL-8 -251 were associated with overall survival (OS). After adjusting for covariates, IL-8 remained significantly associated with TTR (adjusted P = 0. 003) and OS (adjusted P = 0. 049), whereas ES was significantly associated with TTR (adjusted P = 0. 026). V体育ios版.

Conclusions: Polymorphisms in PAR-1, ES, and IL-8 may serve as independent molecular prognostic markers in patients with localized gastric adenocarcinoma. The assessment of the patients' individual risk on the basis of interindividual genotypes may therefore help to identify patient subgroups at high risk for poor clinical outcome. VSports最新版本.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Time to recurrence of patients with localized gastric cancer by (A) PAR-1 −506 ins/del, (B) endostatin +4349 G>A, (C) IL-8 −251 T>A, and (D) combination analysis. Vertical hash marks indicate the time of last follow-up for those patients who have not recurred or died at the time of the analysis of data. All censored patients and those who showed tumor recurrence are accounted for. IL-8, interleukin-8; PAR-1, proteinase-activated receptor.
Figure 2.
Figure 2.
Overall survival of patients with localized gastric cancer by (A) PAR-1 −506 ins/del and (B) IL-8 −251 T>A. Vertical hash marks indicate the time of last follow-up for those patients who have not died at the time of the analysis of data. All censored patients and those who died are accounted for. IL-8, interleukin-8; PAR-1, proteinase-activated receptor.
See this image and copyright information in PMC

References

    1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74–108. - PubMed
    1. Sasako M, Sano T, Yamamoto S, et al. D2 lymphadenectomy alone or with para-aortic nodal dissection for gastric cancer. N Engl J Med. 2008;359:453–462. - PubMed
    1. Macdonald JS, Smalley SR, Benedetti J, et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med. 2001;345:725–730. - "VSports app下载" PubMed
    1. Macdonald JS. Treatment of localized gastric cancer. Semin Oncol. 2004;31:566–573. - PubMed
    1. Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer. 2003;3:401–410. - PubMed

Publication types

MeSH terms