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Review
. 2009 Mar;21(2):144-9.
doi: 10.1097/CCO.0b013e3283252fc5.

Indoor ultraviolet tanning and skin cancer: health risks and opportunities

Affiliations
Review

Indoor ultraviolet tanning and skin cancer: health risks and opportunities

Joshua M Schulman et al. Curr Opin Oncol. 2009 Mar.

Abstract

Purpose of review: Skin cancer incidence is higher than that of any other human malignancy, and yet one of its root causes [ultraviolet (UV) radiation] is perhaps better understood than any other human carcinogen. The roles of UV radiation exposure and indoor tanning behaviors on skin cancer risk are explored here. VSports手机版.

Recent findings: Studies from the past several years have shown a significant association between ever-use of an indoor tanning facility and an increased risk of basal cell carcinoma, squamous cell carcinoma, and melanoma V体育安卓版. The association between indoor tanning and skin cancer is particularly strong among those who first used a tanning facility in early adulthood. Elevated vitamin D levels have been suggested to protect against various internal malignancies and other disease states, but sources of vitamin D that do not require UV exposure are easily available. .

Summary: Although additional research is needed to understand fully the relationship between UV and skin cancer, it is already clear that indoor tanning bed use represents an avoidable risk factor for melanoma and nonmelanoma skin cancer - both of which may be lethal. Acting upon this information provides a unique opportunity for protecting the public health V体育ios版. .

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"VSports在线直播" Figures

Figure 1
Figure 1
Schematic of molecular steps in the tanning and UV-carcinogenesis pathways. DNA damage appears to be a common/proximal intermediate in both pathways.
Figure 2
Figure 2
Relative risk of melanoma associated with early first exposure to indoor tanning: estimates of 7 studies and summary estimate. Reprinted with permission [14**].

References

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    1. Mouret S, Baudouin C, Charveron M, et al. Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation. Proc Natl Acad Sci USA. 2006;103:13765–70. - PMC - PubMed

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