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. 2008 Jun;4(2):84-8.
doi: 10.3988/jcn.2008.4.2.84. Epub 2008 Jun 20.

Multiplex analysis of cytokines in the serum and cerebrospinal fluid of patients with Alzheimer's disease by color-coded bead technology

Chulhee Choi  1 , Jee-Hyang Jeong, Joong Sik Jang, Kyungsun Choi, Jungsul Lee, Jongbum Kwon, Kyoung-Gyu Choi, Jong-Seo Lee, Sang Won Kang
Affiliations

Multiplex analysis of cytokines in the serum and cerebrospinal fluid of patients with Alzheimer's disease by color-coded bead technology

Chulhee Choi (VSports注册入口) et al. J Clin Neurol. 2008 Jun.

Abstract (VSports app下载)

Background and purpose: The availability and promise of effective treatments for neurodegenerative disorders are increasing the importance of early diagnosis. Having molecular and biochemical markers of Alzheimer's disease (AD) would complement clinical approaches, and further the goals of early and accurate diagnosis. Combining multiple biomarkers in evaluations significantly increases the sensitivity and specificity of the biochemical tests. VSports手机版.

Methods: In this study, we used color-coded bead-based Luminex technology to test the potential of using chemokines and cytokines as biochemical markers of AD. We measured the levels of 22 chemokines and cytokines in the serum and cerebrospinal fluid (CSF) of 32 de novo patients (13 controls, 11 AD, and 8 Parkinson's disease [PD]) V体育安卓版. .

Results: MCP-1 was the only cytokine detectable in CSF, and its levels did not differ between control and disease groups V体育ios版. However, the serum concentration of eotaxin was significantly higher in AD patients than in the control group. .

Conclusions: The analysis of multiple inflammatory mediators revealed marginal differences in their CSF and serum concentrations for the differential diagnosis of AD and PD VSports最新版本. These results provide evidence that immunological responses are not major contributors to the pathogenesis of AD and PD. .

Keywords: Alzheimer's disease; Biomarker; Cerebrospinal fluid; Neurodegeneration; Serum. V体育平台登录.

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