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. 2009 Sep;29(5):696-704.
doi: 10.1007/s10875-009-9293-9. Epub 2009 May 22.

"V体育平台登录" Expression of CD62L on donor CD4(+) T cells in allografts: correlation with graft-versus-host disease after unmanipulated allogeneic blood and marrow transplantation

Ying-Jun Chang  1 , Xiang-Yu Zhao, Ming-Rui Huo, Xiao-Jun Huang
Affiliations

VSports app下载 - Expression of CD62L on donor CD4(+) T cells in allografts: correlation with graft-versus-host disease after unmanipulated allogeneic blood and marrow transplantation

Ying-Jun Chang et al. J Clin Immunol. 2009 Sep.

Abstract

Introduction: The aim of this study was to investigate the association of donor CD4(+) T cells expressing CD62L with transplant outcomes VSports手机版. .

Materials and methods: We report a prospective analysis of 31 patients who were treated with a Bu/Cy regimen, followed by unmanipulated blood and marrow transplantation. V体育安卓版.

Results: Median number (range) of CD4(+)CD62L(+), CD4(+)CD45RA(+)CD62L(+), and CD4(+)CD45RO(+)CD62L(+) cells infused were 0. 31(0. 05-1. 10)x10(8)/kg, 0. 22(0. 03-0. 95)x 10(8)/kg, and 0. 17(0. 01-0. 81)x10(8)/kg, respectively. The incidence of grades II to IV aGVHD was 36%. In a multivariate analysis, infusion of >0. 22 x 10(8) CD4(+)CD45RA(+)CD62L(+) cells infused/kg increased the risk of grades II to IV aGVHD (HR = 4. 741, 95% CI = 1. 037-21. 662, P = 0. 045) V体育ios版. Thirteen of 31 patients experienced cGVHD, the risk of cGVHD was increased in patients receiving >0. 45 x 10(8) CD4(+)CD45RA(+) cells infused/kg (HR = 4. 614, 95% CI = 1. 265-16. 829, P = 0. 021). .

Conclusion: Our results suggest that a high cell dose of CD4(+)CD45RA(+)CD62L(+) cells increase the incidence of grades II-IV aGVHD. A high number of CD4(+)CD45RA(+) cells infused were associated with increased risk of cGVHD in our transplant settings VSports最新版本. .

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