VSports注册入口 - Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site VSports app下载. .

Https

The site is secure V体育官网. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. .

. 2008 Sep;10(9):1051-61.
doi: 10.1038/ncb1764.

A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth (V体育官网)

Michael Wanzel  1 , Annika C Russ, Daniela Kleine-Kohlbrecher, Emanuela Colombo, Pier-Guiseppe Pelicci, Martin Eilers
Affiliations

"V体育ios版" A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth

Michael Wanzel et al. Nat Cell Biol. 2008 Sep.

Abstract (V体育2025版)

The Myc-associated zinc-finger protein, Miz1, is a negative regulator of cell proliferation and induces expression of the cell-cycle inhibitors p15(Ink4b) and p21(Cip1). Here we identify the ribosomal protein L23 as a negative regulator of Miz1-dependent transactivation. L23 exerts this function by retaining nucleophosmin, an essential co-activator of Miz1 required for Miz1-induced cell-cycle arrest, in the nucleolus. Mutant forms of nucleophosmin found in acute myeloid leukaemia fail to co-activate Miz1 and re-localize it to the cytosol VSports手机版. As L23 is encoded by a direct target gene of Myc, this regulatory circuit may provide a feedback mechanism that links translation of Myc target genes and cell growth to Miz1-dependent cell-cycle arrest. .

PubMed Disclaimer

Publication types

MeSH terms