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. 2009 Jan 6;15(1):67-78.
doi: 10.1016/j.ccr.2008.12.005.

Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma (VSports手机版)

Tobias Otto  1 , Sebastian Horn, Markus Brockmann, Ursula Eilers, Lars Schüttrumpf, Nikita Popov, Anna Marie Kenney, Johannes H Schulte, Roderick Beijersbergen, Holger Christiansen, Bernd Berwanger, Martin Eilers
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V体育官网入口 - Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma

Tobias Otto et al. Cancer Cell. .
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"VSports" Abstract

In human neuroblastoma, amplification of the MYCN gene predicts poor prognosis and resistance to therapy. In a shRNA screen of genes that are highly expressed in MYCN-amplified tumors, we have identified AURKA as a gene that is required for the growth of MYCN-amplified neuroblastoma cells but largely dispensable for cells lacking amplified MYCN. Aurora A has a critical function in regulating turnover of the N-Myc protein. Degradation of N-Myc requires sequential phosphorylation by cyclin B/Cdk1 and Gsk3 VSports手机版. N-Myc is therefore degraded during mitosis in response to low levels of PI3-kinase activity. Aurora A interacts with both N-Myc and the SCF(Fbxw7) ubiquitin ligase that ubiquitinates N-Myc and counteracts degradation of N-Myc, thereby uncoupling N-Myc stability from growth factor-dependent signals. .

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