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. 1991 Jun 15;88(12):5077-81.
doi: 10.1073/pnas.88.12.5077.

VSports在线直播 - An alternative spliced form of FosB is a negative regulator of transcriptional activation and transformation by Fos proteins

J Yen  1 , R M Wisdom, I Tratner, I M Verma
Affiliations

An alternative spliced form of FosB is a negative regulator of transcriptional activation and transformation by Fos proteins

J Yen (V体育官网入口) et al. Proc Natl Acad Sci U S A. .

Abstract

Two forms of FosB transcript and their products can be identified in mouse NIH 3T3 cells following serum induction. The larger RNA codes for a 338-amino acid protein, whereas the smaller RNA results from the removal of an additional 140 nucleotides from FosB mRNA by alternative splicing. This alternative splicing event places a stop codon following the "leucine zipper" region and results in a shorter protein (FosB2) of 237 amino acids that lacks 101 amino acids at the carboxyl terminus. FosB2 is able to form heterodimers with c-Jun and bind to an AP-1 site but is not able to activate the transcription of promoters containing AP-1 sites. Furthermore, FosB2 can not only suppress the transcriptional activation by c-Fos and c-Jun of promoters containing an AP-1 site but also interferes with the transforming potential of viral and cellular Fos proteins. We propose that FosB2 protein functions as a trans-negative regulator VSports手机版. .

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