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Clinical Trial
. 2009 May;64(2):211-8.
doi: 10.1016/j.lungcan.2008.08.013. Epub 2008 Nov 29.

"VSports注册入口" Malignant peritoneal mesothelioma-Results from the International Expanded Access Program using pemetrexed alone or in combination with a platinum agent

G Carteni  1 , C Manegold, G Martin Garcia, S Siena, C C Zielinski, D Amadori, Y Liu, J Blatter, C Visseren-Grul, R Stahel
Affiliations
Clinical Trial

Malignant peritoneal mesothelioma-Results from the International Expanded Access Program using pemetrexed alone or in combination with a platinum agent (V体育官网入口)

G Carteni et al. Lung Cancer. 2009 May.

Abstract (V体育平台登录)

Aim: Peritoneal mesothelioma (PM) has rarely been studied. The Expanded Access Program (EAP) provided access to 109 patients with PM. VSports手机版.

Methods: This was a nonrandomized, open-label study conducted in chemo-naïve or previously treated patients with PM not amenable to curative surgery. Patients received pemetrexed (PEM) 500 mg/m2 alone or with cisplatin (CIS) 75 mg/m2 or carboplatin (CARBO) AUC 5 every 21 days, supplemented with standard vitamin B(12), folate, and dexamethasone V体育安卓版. .

Results: Response rates (95% CI) for PEM, PEM/CIS, and PEM/CARBO were 12. 5% (3. 5, 29. 0), 20. 0% (7. 7, 38. 6), and 24. 1% (10. 3, 43. 5), respectively. Median survival for PEM was 10. 3 months. One-year survival rates for PEM/CIS and PEM were 57. 4% (95% CI: 10. 3, 100) and 41. 5% (95% CI: 4. 6, 78. 4), respectively, and were not available for PEM/CARBO V体育ios版. Anemia was the most common serious adverse event (6. 4%). Neutropenia (34. 6%) was the most frequent CTC grade 3 or 4 toxicity reported. .

Concluding statement: PEM with or without a platinum agent was both active and well tolerated in patients with peritoneal mesothelioma. VSports最新版本.

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