Background/aims: To determine whether gender, age, hepatitis B virus genotype, core promoter and precore mutations, HBeAg/ anti-HBe status, HBV DNA, ALT levels and cirrhosis on presentation were independent risk factors and derive a novel risk score for the development of HCC VSports手机版. .

Methods: CHB patients (820) were followed up (mean duration 76. 8 months) for the occurrence of HCC V体育安卓版. .

Results: The 5- and 10-year prevalence of HCC were 4. 4% and 6. 3%, respectively V体育ios版. Cox regression analysis showed that male gender (p = 0. 025, RR 2. 98), increasing age (p < 0. 001, RR 1. 07), higher HBV DNA levels (p = 0. 02, RR 1. 28), core promoter mutations (p = 0. 007, RR 3. 66), and presence of cirrhosis (p < 0. 001, RR 7. 31) were independent risks for the development of HCC. A risk score was derived and validated with sensitivity > 84% and specificity > 76% to predict the 5- and 10- year risks for the development of HCC. The AUC for the 5- and 10-year prediction were 0. 88 and 0. 89, respectively. .

Conclusions: The risk score, based on age, gender, HBV DNA levels, core promoter mutations and cirrhosis, can estimate the chance of development of HCC in 5 and 10 years after presentation. It can be used to identify high-risk CHB patients for treatment and screening of HCC. VSports最新版本.