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Review
. 2008 Dec;18(6):423-36.
doi: 10.1016/j.semcancer.2008.09.003. Epub 2008 Oct 2.

Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis

Chengyu Liang  1 , Jong-Soo Lee, Jae U Jung
Affiliations
Review

Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis (V体育2025版)

"V体育2025版" Chengyu Liang et al. Semin Cancer Biol. 2008 Dec.

Abstract

A hallmark of herpesviruses is a lifelong persistent infection, which often leads to diseases upon immune suppression of infected host. Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8), is etiologically linked to the development of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD) VSports手机版. In order to establish a persistent infection, KSHV dedicates a large portion of its genomic information to sabotage almost every aspect of host immune system. Thus, understanding the interplay between KSHV and the host immune system is important in not only unraveling the complexities of viral persistence and pathogenesis, but also discovering novel therapeutic targets. This review summarizes current knowledge of host immune evasion strategies of KSHV and their contributions to KSHV-associated diseases. .

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VSports注册入口 - Figures

Fig. 1.
Fig. 1.
Schematic representation of KSHV immune evasion strategies.
See this image and copyright information in PMC

References

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