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. 2008 Oct;15(4):521-33.
doi: 10.1016/j.devcel.2008.09.005.

Compensatory growth of healthy cardiac cells in the presence of diseased cells restores tissue homeostasis during heart development

Jörg-Detlef Drenckhahn  1 , Quenten P Schwarz, Stephen Gray, Adrienne Laskowski, Helen Kiriazis, Ziqiu Ming, Richard P Harvey, Xiao-Jun Du, David R Thorburn, Timothy C Cox
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Compensatory growth of healthy cardiac cells in the presence of diseased cells restores tissue homeostasis during heart development (VSports app下载)

"V体育平台登录" Jörg-Detlef Drenckhahn et al. Dev Cell. 2008 Oct.
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"V体育平台登录" Abstract

Energy generation by mitochondrial respiration is an absolute requirement for cardiac function. Here, we used a heart-specific conditional knockout approach to inactivate the X-linked gene encoding Holocytochrome c synthase (Hccs), an enzyme responsible for activation of respiratory cytochromes c and c1. Heterozygous knockout female mice were thus mosaic for Hccs function due to random X chromosome inactivation. In contrast to midgestational lethality of Hccs knockout males, heterozygous females appeared normal after birth. Analyses of heterozygous embryos revealed the expected 50:50 ratio of Hccs deficient to normal cardiac cells at midgestation; however, diseased tissue contributed progressively less over time and by birth represented only 10% of cardiac tissue volume VSports手机版. This change is accounted for by increased proliferation of remaining healthy cardiac cells resulting in a fully functional heart. These data reveal an impressive regenerative capacity of the fetal heart that can compensate for an effective loss of 50% of cardiac tissue. .

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