Background: Recent studies suggest that proton-pump inhibitors (PPIs) may increase the risk for community-acquired pneumonia (CAP). VSports手机版.

Objective: To examine the association between PPI use and CAP in adults followed in general practices in the United Kingdom V体育安卓版. .

Design: Nested case-control study. V体育ios版.

Setting: The General Practice Research Database (1987 to 2002) in the United Kingdom VSports最新版本. .

Participants: Patients age 18 years or older with at least 6 months of initial pneumonia-free follow-up in the database. Case patients (n = 80 066) were defined as those who received an incident diagnosis of CAP. Control participants (n = 799 881) were selected by using incidence density sampling, matching on practice site, calendar period, and follow-up duration V体育平台登录. .

Measurements: Use of PPIs within 30 days before the index date. Adjusted odds ratios (ORs) were estimated by using conditional logistic regression, adjusting for potential confounders VSports注册入口. .

Results: Overall, current PPI use was not associated with an increased risk for CAP (adjusted OR, 1. 02 [95% CI, 0. 97 to 1. 08]) or risk for CAP that required hospitalization (adjusted OR, 1. 01 [CI, 0 V体育官网入口. 91 to 1. 12]). There was a strong increase in risk for CAP associated with current use of PPI therapy that was started within the previous 2 days (adjusted OR, 6. 53 [CI, 3. 95 to 10. 80]), 7 days (adjusted OR, 3. 79 [CI, 2. 66 to 5. 42]), and 14 days (adjusted OR, 3. 21 [CI, 2. 46 to 4. 18]), but there was no statistically significant association for longer-term current PPI therapy. A separate matched case-control analysis, which included the 3 strongest confounders as additional matching factors, yielded similar results as the primary analysis (adjusted OR, 0. 96 [CI, 0. 91 to 1. 02]). .

Limitations: Adherence to PPI prescription was assumed to be 100%. No radiographic evidence was available to corroborate a diagnosis of CAP VSports在线直播. .

Conclusion: Proton-pump inhibitor therapy started within the past 30 days was associated with an increased risk for CAP, whereas longer-term current use was not.