<style draggable="3Qhvkym"><noframes date-time="0gWBKTdC"><code dropzone="Trule"></code> Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in VSports app下载. gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure V体育官网. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. .

Case Reports
. 2008 Oct;47(10):884-9.
doi: 10.1002/gcc.20585.

"V体育ios版" Novel SSBP2-JAK2 fusion gene resulting from a t(5;9)(q14.1;p24.1) in pre-B acute lymphocytic leukemia

Jennifer L Poitras  1 , Paola Dal Cin, Jon C Aster, Daniel J Deangelo, Cynthia C Morton
Affiliations
Case Reports

Novel SSBP2-JAK2 fusion gene resulting from a t(5;9)(q14.1;p24.1) in pre-B acute lymphocytic leukemia

Jennifer L Poitras et al. Genes Chromosomes Cancer. 2008 Oct.

Abstract

Activating mutations in JAK2 are found in virtually all patients with polycythemia vera, and about half of those with essential thrombocythemia and primary myelofibrosis. In addition, less common aberrations (particularly gene fusions) involving JAK2 have been described in acute leukemias. With the advent of JAK2 inhibitor trials in myeloproliferative disorders, tumors with JAK2 mutations or rearrangements have become candidates for targeted therapy. In this report, we identify SSBP2 as a new JAK2 fusion partner in a patient with pre-B cell acute lymphocytic leukemia. This finding adds to the expanding compendium of JAK2 aberrations found in various hematopoietic malignancies, as well as the potential need for a diagnostic FISH analysis in the appropriate clinical setting. VSports手机版.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources