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. 2008 Jun 1;177(11):1242-7.
doi: 10.1164/rccm.200712-1777OC. Epub 2008 Mar 27.

VSports最新版本 - Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis

Sachin Yende  1 , Gina D'Angelo, John A Kellum, Lisa Weissfeld, Jonathan Fine, Robert D Welch, Lan Kong, Melinda Carter, Derek C Angus; GenIMS Investigators
Collaborators, Affiliations

V体育安卓版 - Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis

Sachin Yende et al. Am J Respir Crit Care Med. .

Abstract

Rationale: Survivors of hospitalization for community-acquired pneumonia (CAP) are at increased risk of cardiovascular events, repeat infections, and death in the following months but the cause is unknown. VSports手机版.

Objectives: To investigate whether persistent inflammation, defined as elevating circulating inflammatory markers at hospital discharge, is associated with subsequent outcomes. V体育安卓版.

Methods: Prospective cohort study at 28 sites V体育ios版. .

Measurements and main results: We used standard criteria to define CAP and the National Death Index to determine all-cause and cause-specific 1-year mortality. At hospital discharge, 1,799 subjects (77. 5%) were alive and vital signs had returned to normal in 1,512 (87%) subjects. The geometric means (+/-SD) for circulating IL-6 and IL-10 concentrations were 6. 9 (+/-1) pg/ml and 1. 2 (+/-1. 1) pg/ml. At 1 year, 307 (17. 1%) subjects had died VSports最新版本. Higher IL-6 and IL-10 concentrations at hospital discharge were associated with an increased risk of death, which gradually fell over time. Using Gray's survival model, the associations were independent of demographics, comorbidities, and severity of illness (for each log-unit increase, the range of adjusted hazard ratios [HRs] for IL-6 were 1. 02-1. 46, P < 0. 0001, and for IL-10 were 1. 17-1. 44, P = 0. 01). The ranges of HRs for each log-unit increase in IL-6 and IL-10 concentrations among subjects who did and did not develop severe sepsis were 0. 95-1. 27 and 1. 07-1. 55, respectively. High IL-6 concentrations were associated with death due to cardiovascular disease, cancer, infections, and renal failure (P = 0. 008). .

Conclusions: Despite clinical recovery, many patients with CAP leave hospital with ongoing subclinical inflammation, which is associated with an increased risk of death V体育平台登录. .

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Figures

<b>Figure 1.</b>
Figure 1.
Subject disposition for the entire Genetic and Inflammatory Markers of Sepsis (GenIMS) cohort. CAP = community-acquired pneumonia.
<b>Figure 2.</b>
Figure 2.
Failure plots for circulating IL-6 (A) and IL-10 (B) concentrations and mortality over 1 year. High and low concentrations are the 10th and 90th percentiles of cytokine concentrations. Using the Gray's model, the hazard ratios are estimated over 10 intervals (with 11 time nodes) over 1 year and hazard ratios over five representative periods are shown. P values are obtained from the Gray's survival model.
<b>Figure 3.</b>
Figure 3.
Varying hazard ratios with 95% confidence intervals (CI) for IL-6 (A) and IL-10 (B) and risk of death over 1 year. The hazard ratios are shown over 10 intervals (with 11 time nodes), based on the Gray's model. For IL-6, the 95% CI is above 1 for 100 days, whereas for IL-10 the 95% CI is above 1 for 177 days or approximately 6 months.
<b>Figure 3.</b>
Figure 3.
Varying hazard ratios with 95% confidence intervals (CI) for IL-6 (A) and IL-10 (B) and risk of death over 1 year. The hazard ratios are shown over 10 intervals (with 11 time nodes), based on the Gray's model. For IL-6, the 95% CI is above 1 for 100 days, whereas for IL-10 the 95% CI is above 1 for 177 days or approximately 6 months.
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References

    1. Kaplan V, Clermont G, Griffin MF, Kasal J, Watson RS, Linde-Zwirble WT, Angus DC. Pneumonia: still the old man's friend? Arch Intern Med 2003;163:317–323. - PubMed
    1. LaCroix AZ, Lipson S, Miles TP, White L. Prospective study of pneumonia hospitalizations and mortality of U.S. older people: the role of chronic conditions, health behaviors, and nutritional status. Public Health Rep 1989;104:350–360. - PMC - PubMed
    1. Brancati FL, Chow JW, Wagener MM, Vacarello SJ, Yu VL. Is pneumonia really the old man's friend? Two-year prognosis after community-acquired pneumonia. Lancet 1993;342:30–33. - PubMed
    1. Koivula I, Sten M, Makela PH. Prognosis after community-acquired pneumonia in the elderly: a population-based 12-year follow-up study. Arch Intern Med 1999;159:1550–1555. - PubMed
    1. Waterer GW, Kessler LA, Wunderink RG. Medium-term survival after hospitalization with community-acquired pneumonia. Am J Respir Crit Care Med 2004;169:910–914. - PubMed

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