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. 2008 Feb 29;319(5867):1244-7.
doi: 10.1126/science.1153124.

Ceramide triggers budding of exosome vesicles into multivesicular endosomes

Katarina Trajkovic  1 , Chieh Hsu, Salvatore Chiantia, Lawrence Rajendran, Dirk Wenzel, Felix Wieland, Petra Schwille, Britta Brügger, Mikael Simons
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Ceramide triggers budding of exosome vesicles into multivesicular endosomes

Katarina Trajkovic et al. Science. .

V体育官网 - Abstract

Intraluminal vesicles of multivesicular endosomes are either sorted for cargo degradation into lysosomes or secreted as exosomes into the extracellular milieu. The mechanisms underlying the sorting of membrane into the different populations of intraluminal vesicles are unknown. Here, we find that cargo is segregated into distinct subdomains on the endosomal membrane and that the transfer of exosome-associated domains into the lumen of the endosome did not depend on the function of the ESCRT (endosomal sorting complex required for transport) machinery, but required the sphingolipid ceramide VSports手机版. Purified exosomes were enriched in ceramide, and the release of exosomes was reduced after the inhibition of neutral sphingomyelinases. These results establish a pathway in intraendosomal membrane transport and exosome formation. .

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Comment in (V体育安卓版)

  • Cell biology. No ESCRTs for exosomes.
    Marsh M, van Meer G. Marsh M, et al. Science. 2008 Feb 29;319(5867):1191-2. doi: 10.1126/science.1155750. Science. 2008. PMID: 18309064 No abstract available.

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V体育官网 - MeSH terms