Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. VSports app下载.

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. V体育官网.

. 2007 Nov 8;56(3):517-29.
doi: 10.1016/j.neuron.2007.09.032.

Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli (V体育安卓版)

William Renthal  1 , Ian Maze, Vaishnav Krishnan, Herbert E Covington 3rd, Guanghua Xiao, Arvind Kumar, Scott J Russo, Ami Graham, Nadia Tsankova, Tod E Kippin, Kerry A Kerstetter, Rachael L Neve, Stephen J Haggarty, Timothy A McKinsey, Rhonda Bassel-Duby, Eric N Olson, Eric J Nestler
Affiliations
Free article

Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli

William Renthal et al. Neuron. .
Free article

Abstract

Previous work has identified alterations in histone acetylation in animal models of drug addiction and depression. However, the mechanisms which integrate drugs and stress with changes in chromatin structure remain unclear. Here, we identify the activity-dependent class II histone deacetylase, HDAC5, as a central integrator of these stimuli with changes in chromatin structure and gene expression VSports手机版. Chronic, but not acute, exposure to cocaine or stress decreases HDAC5 function in the nucleus accumbens (NAc), a major brain reward region, which allows for increased histone acetylation and transcription of HDAC5 target genes. This regulation is behaviorally important, as loss of HDAC5 causes hypersensitive responses to chronic, not acute, cocaine or stress. These findings suggest that proper balance of histone acetylation is a crucial factor in the saliency of a given stimulus and that disruption of this balance is involved in the transition from an acute adaptive response to a chronic psychiatric illness. .

PubMed Disclaimer

Comment in

Publication types

MeSH terms

Associated data