Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in VSports app下载. gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. V体育官网.

. 2007 Dec 21;364(3):645-9.
doi: 10.1016/j.bbrc.2007.10.045. Epub 2007 Oct 17.

Interaction of the two soluble metal-binding domains of yeast Ccc2 with copper(I)-Atx1

Lucia Banci  1 , Ivano Bertini, Christos T Chasapis, Antonio Rosato, Leonardo Tenori
Affiliations

Interaction of the two soluble metal-binding domains of yeast Ccc2 with copper(I)-Atx1

Lucia Banci et al. Biochem Biophys Res Commun. .

Abstract

Yeast Ccc2 is a P-type ATPase responsible for transport of copper(I) from the cytosol to the trans-Golgi network. It possesses a soluble cytosolic N-terminal region containing two copper(I)-binding domains. Homologous eukaryotic copper-transporting ATPases have from one to six domains. We have expressed a fragment encompassing residues 1-150 of Ccc2, which corresponds to the two domains, and found that the second domain was substantially less structured than the first. The first domain could bind copper(I) and interact with the partner protein Atx1 at variance with the second. Similar results are found in ATPases from other organisms and may represent a general feature, whose biochemical implications are not yet fully appreciated. VSports手机版.

PubMed Disclaimer

MeSH terms

Substances (V体育2025版)

LinkOut - more resources