Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site VSports app下载. .

Https

The site is secure V体育官网. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. .

. 2007 Sep 7;130(5):797-810.
doi: 10.1016/j.cell.2007.06.049.

"V体育官网入口" A common mechanism of cellular death induced by bactericidal antibiotics

Michael A Kohanski  1 , Daniel J Dwyer, Boris Hayete, Carolyn A Lawrence, James J Collins
Affiliations
Free article

A common mechanism of cellular death induced by bactericidal antibiotics

"VSports手机版" Michael A Kohanski et al. Cell. .
Free article

Abstract

Antibiotic mode-of-action classification is based upon drug-target interaction and whether the resultant inhibition of cellular function is lethal to bacteria VSports手机版. Here we show that the three major classes of bactericidal antibiotics, regardless of drug-target interaction, stimulate the production of highly deleterious hydroxyl radicals in Gram-negative and Gram-positive bacteria, which ultimately contribute to cell death. We also show, in contrast, that bacteriostatic drugs do not produce hydroxyl radicals. We demonstrate that the mechanism of hydroxyl radical formation induced by bactericidal antibiotics is the end product of an oxidative damage cellular death pathway involving the tricarboxylic acid cycle, a transient depletion of NADH, destabilization of iron-sulfur clusters, and stimulation of the Fenton reaction. Our results suggest that all three major classes of bactericidal drugs can be potentiated by targeting bacterial systems that remediate hydroxyl radical damage, including proteins involved in triggering the DNA damage response, e. g. , RecA. .

PubMed Disclaimer

"V体育安卓版" Comment in

"V体育2025版" Publication types

MeSH terms

Substances