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. 2007 Sep 7;13(33):4504-8.
doi: 10.3748/wjg.v13.i33.4504.

"VSports" Association of the frequency of peripheral natural killer T cells with nonalcoholic fatty liver disease

Cheng-Fu Xu  1 , Chao-Hui Yu, You-Ming Li, Lei Xu, Juan Du, Zhe Shen
Affiliations

VSports注册入口 - Association of the frequency of peripheral natural killer T cells with nonalcoholic fatty liver disease

Cheng-Fu Xu et al. World J Gastroenterol. .

Abstract

Aim: To investigate whether changes in the frequency of peripheral natural killer T (NKT) cells were correlated with liver disease in patients who had metabolic predispositions to nonalcoholic fatty liver disease (NAFLD). VSports手机版.

Methods: Peripheral blood samples were obtained from 60 Chinese NAFLD patients and 60 age and gender matched healthy controls V体育安卓版. The frequency of peripheral NKT cells was detected by flow cytometry. Clinical and laboratory data were collected for further analysis. .

Results: NAFLD patients had a lower frequency of peripheral NKT cells than healthy controls (1. 21% +/- 0. 06% vs 1. 62% +/- 0. 07%, P < 0. 001) V体育ios版. Further analysis revealed that the frequency of peripheral NKT cells was negatively correlated with body mass index, waist circumference and serum levels of alanine aminotransferase. Logistic regression analysis revealed that elevated body mass index [hazard ratio (HR): 2. 991], aspartate aminotransferase levels (HR: 1. 148) and fasting blood sugar (HR: 3. 133) increased the risk of NAFLD, whereas an elevated frequency of peripheral NKT cells (HR: 0. 107) decreased the risk. .

Conclusion: Changes in the frequency of peripheral NKT cells were correlated with NAFLD and a decreased frequency of peripheral NKT cells was a risk factor for NAFLD. VSports最新版本.

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Figures

Figure 1
Figure 1
Frequency of peripheral NKT cells in NAFLD patients versus healthy controls. Boxes show values within 25th and 75th percentiles, horizontal bar represents the median, 80% of values are between the extremities of vertical bars (10th-90th percentiles), and extreme values are represented by individual symbols. bP < 0.001 vs healthy controls.
Figure 2
Figure 2
Relationships between the frequency of peripheral NKT cells and BMI, waist circumference and ALT. A: The frequency of peripheral NKT cells was compared between the subjects with BMI ≥ 24 kg/m2 (n = 68) and the subjects with BMI < 24 kg/m2 (n = 52), bP < 0.01 vs subjects with BMI < 24 kg/m2; B: The frequency of peripheral NKT cells was compared between the subjects with waist circumference ≥ 90 cm for male and ≥ 85 cm for female (n = 47) and the subjects with normal waist circumference (n = 73), aP < 0.05 vs subjects with normal waist circumference; C: The frequency of peripheral NKT cells was compared between the subjects with ALT ≥ 50 U/L (n = 21) and the subjects with ALT < 50 U/L (n = 99), cP < 0.01 vs subjects with ALT < 50 U/L.
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V体育2025版 - References

    1. Jimba S, Nakagami T, Takahashi M, Wakamatsu T, Hirota Y, Iwamoto Y, Wasada T. Prevalence of non-alcoholic fatty liver disease and its association with impaired glucose metabolism in Japanese adults. Diabet Med. 2005;22:1141–1145. - PubMed
    1. Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology. 2003;37:1202–1219. - PubMed
    1. Reid AE. Nonalcoholic steatohepatitis. Gastroenterology. 2001;121:710–723. - PubMed (VSports在线直播)
    1. Bendelac A, Rivera MN, Park SH, Roark JH. Mouse CD1-specific NK1 T cells: development, specificity, and function. Annu Rev Immunol. 1997;15:535–562. - V体育平台登录 - PubMed
    1. Vincent MS, Gumperz JE, Brenner MB. Understanding the function of CD1-restricted T cells. Nat Immunol. 2003;4:517–523. - "V体育平台登录" PubMed