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. 2007 Aug 1;179(3):1489-96.
doi: 10.4049/jimmunol.179.3.1489.

"V体育官网" CD8+ dendritic cells use LFA-1 to capture MHC-peptide complexes from exosomes in vivo

Elodie Segura  1 , Coralie Guérin, Nancy Hogg, Sebastian Amigorena, Clotilde Théry
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"VSports注册入口" CD8+ dendritic cells use LFA-1 to capture MHC-peptide complexes from exosomes in vivo

Elodie Segura et al. J Immunol. .

"V体育2025版" Abstract

Exosomes are secreted vesicles formed in late endocytic compartments. Mature dendritic cells (DCs) secrete exosomes bearing functional MHC-peptide complexes and high levels of ICAM-1 VSports手机版. Such exosomes can activate Ag-specific naive T cells but only after recapture by recipient APCs. In this study, we addressed the molecular mechanisms of interaction between exosomes and recipient DCs. We show that exosomes can be presented by mouse DCs without the need for internalization and processing. Exosomes interact with DCs through a specific saturable receptor. Although the two major ligands of ICAM-1, LFA-1 and Mac-1, are expressed by lymphoid organ DCs, only LFA-1 is required for exosome capture by these cells. Accordingly, we show that CD8(+) DCs express higher levels of LFA-1 than CD8(-) DCs, and that they are the main recipients of exosomes in vivo. We propose a new role for LFA-1 on DCs, as a receptor for exosomes to favor Ag transfer between DCs in vivo. .

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