Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or VSports app下载. mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. V体育官网.

. 2007 Aug;29(1):52-9.
doi: 10.1016/j.jaut.2007.04.004. Epub 2007 Jun 4.

Coactivation of Toll-like receptor-3 and -7 in immune complex glomerulonephritis

Prashant S Patole  1 , Rahul D Pawar, Julia Lichtnekert, Maciej Lech, Onkar P Kulkarni, Allam Ramanjaneyulu, Stephan Segerer, Hans-Joachim Anders
Affiliations

Coactivation of Toll-like receptor-3 and -7 in immune complex glomerulonephritis

Prashant S Patole et al. J Autoimmun. 2007 Aug.

"VSports app下载" Abstract

The molecular mechanisms of viral infection-induced glomerulonephritis are poorly understood. Toll-like receptor (TLR)-3 and TLR7 recognize viral RNA and their exposure to TLR3 or TLR7 can trigger the exacerbation of established immune complex disease in MRLlpr mice. Because coactivation of TLR3 and TLR7 was shown to synergistically activate dendritic cells in vitro, we hypothesized that simultaneous ligation of TLR3 and TLR7 would elicit additive effects on the exacerbation of glomerulonephritis in MRLlpr mice. Saline, 50 microg pI:C RNA, 25 microg of the TLR7 agonist imiquimod, or a combination of both were injected every other day to MRLlpr mice from week 16-18 of age. Coinjection of pI:C RNA and imiquimod had no synergistic effect on serum levels of IL-6 and IL12p70, dsDNA autoantibody levels, and glomerulonephritis. This was consistent with a lack of synergistic effects on cytokine release of TNF- and IFNgamma-prestimulated monocytes in vitro. Furthermore, in glomerular mesangial cells a synergistic effect of pI:C RNA and imiquimod was generally absent due to the lack of TLR7 expression. We conclude that a number of mechanisms protect the host from additive effects of TLR3-TLR7 coactivation on renal pathology in vivo VSports手机版. .

PubMed Disclaimer

Publication types (VSports手机版)

MeSH terms (V体育安卓版)

LinkOut - more resources