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Review
. 2007 Apr;8(4):275-83.
doi: 10.1038/nrm2147.

p53 in health and disease

Karen H Vousden  1 , David P Lane
Affiliations
Review

p53 in health and disease

Karen H Vousden et al. Nat Rev Mol Cell Biol. 2007 Apr.

Abstract

As a component of the response to acute stress, p53 has a well established role in protecting against cancer development. However, it is now becoming clear that p53 can have a much broader role and can contribute to the development, life expectancy and overall fitness of an organism VSports手机版. Although the function of p53 as a tumour suppressor ensures that we can't live without it, an integrated view of p53 suggests that not all of its functions are conducive to a long and healthy life. .

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