<b dropzone="UJ6TJH"></b>
Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The VSports app下载. gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure V体育官网. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. .

. 2007 Mar 15;67(6):2649-56.
doi: 10.1158/0008-5472.CAN-06-1823.

Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors (V体育2025版)

Jeffrey B Wyckoff  1 , Yarong Wang, Elaine Y Lin, Jiu-feng Li, Sumanta Goswami, E Richard Stanley, Jeffrey E Segall, Jeffrey W Pollard, John Condeelis
Affiliations

V体育官网入口 - Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors

Jeffrey B Wyckoff et al. Cancer Res. .

Abstract

Although the presence of macrophages in tumors has been correlated with poor prognosis, until now there was no direct observation of how macrophages are involved in hematogenous metastasis. In this study, we use multiphoton microscopy to show, for the first time, that tumor cell intravasation occurs in association with perivascular macrophages in mammary tumors. Furthermore, we show that perivascular macrophages of the mammary tumor are associated with tumor cell intravasation in the absence of local angiogenesis VSports手机版. These results show that the interaction between macrophages and tumor cells lying in close proximity defines a microenvironment that is directly involved in the intravasation of cancer cells in mammary tumors. .

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources (VSports)