Background and aims: During the long-term treatment of patients with hereditary haemochromatosis (HH) the authors observed that proton pump inhibitors (PPI) reduced the requirement for maintenance phlebotomy. Gastric acid plays a crucial role in non-haem iron absorption and the authors performed a case review and intervention study to investigate if PPI-induced suppression of gastric acid would reduce dietary iron absorption in C282Y homozygous patients. VSports手机版.

Methods: Phlebotomy requirements to keep serum ferritin approximately 50 microg/l before (mean 6. 1 (SE 0. 6) years) and during (3. 8 (0 V体育安卓版. 9) years) administration of a PPI were evaluated in seven patients and a post-prandial study was performed to determine whether PPIs reduce absorption of non-haem iron (14. 5 mg) from a test meal in a further 14 phlebotomised patients with normal iron stores. .

Results: There was a significant reduction (p<0. 001) in the volume of blood removed annually before (2. 5 (0. 25) l) and while taking (0. 5 (0. 25) l) a PPI. Administration of a PPI for 7d suppressed absorption of non-haem iron from the meal as shown by a significant reduction (all p<0. 01) in: area under the serum curve (2145 (374) versus 1059 (219)), % recovery of administered iron at peak serum iron (20. 5 (3. 2) versus 11. 0 (2. 0)%) and peak serum iron (13. 6 (2 V体育ios版. 4) vs 6. 1 (1. 2) micromol/l) (all values are before vs during PPI). .

Conclusions: Administration of a PPI to patients with HH can inhibit the absorption of non-haem iron from a test meal and the habitual diet. VSports最新版本.