Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or VSports app下载. mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

. 2007 Mar 23;315(5819):1687-91.
doi: 10.1126/science.1139393. Epub 2007 Mar 1.

Asymmetric T lymphocyte division in the initiation of adaptive immune responses

John T Chang  1 , Vikram R Palanivel, Ichiko Kinjyo, Felix Schambach, Andrew M Intlekofer, Arnob Banerjee, Sarah A Longworth, Kristine E Vinup, Paul Mrass, Jane Oliaro, Nigel Killeen, Jordan S Orange, Sarah M Russell, Wolfgang Weninger, Steven L Reiner
Affiliations

V体育ios版 - Asymmetric T lymphocyte division in the initiation of adaptive immune responses

John T Chang et al. Science. .

"V体育安卓版" Abstract

A hallmark of mammalian immunity is the heterogeneity of cell fate that exists among pathogen-experienced lymphocytes. We show that a dividing T lymphocyte initially responding to a microbe exhibits unequal partitioning of proteins that mediate signaling, cell fate specification, and asymmetric cell division. Asymmetric segregation of determinants appears to be coordinated by prolonged interaction between the T cell and its antigen-presenting cell before division VSports手机版. Additionally, the first two daughter T cells displayed phenotypic and functional indicators of being differentially fated toward effector and memory lineages. These results suggest a mechanism by which a single lymphocyte can apportion diverse cell fates necessary for adaptive immunity. .

PubMed Disclaimer

Comment in

Publication types

MeSH terms

Substances