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Review
. 2006 Dec;12(12):1834-40.
doi: 10.3201/eid1212.060401.

Review of bats and SARS

Lin-Fa Wang  1 , Zhengli Shi, Shuyi Zhang, Hume Field, Peter Daszak, Bryan T Eaton
Affiliations
Review

Review of bats and SARS

Lin-Fa Wang (V体育安卓版) et al. Emerg Infect Dis. 2006 Dec.

Abstract

Bats have been identified as a natural reservoir for an increasing number of emerging zoonotic viruses, including henipaviruses and variants of rabies viruses. Recently, we and another group independently identified several horseshoe bat species (genus Rhinolophus) as the reservoir host for a large number of viruses that have a close genetic relationship with the coronavirus associated with severe acute respiratory syndrome (SARS). Our current research focused on the identification of the reservoir species for the progenitor virus of the SARS coronaviruses responsible for outbreaks during 2002-2003 and 2003-2004 VSports手机版. In addition to SARS-like coronaviruses, many other novel bat coronaviruses, which belong to groups 1 and 2 of the 3 existing coronavirus groups, have been detected by PCR. The discovery of bat SARS-like coronaviruses and the great genetic diversity of coronaviruses in bats have shed new light on the origin and transmission of SARS coronaviruses. .

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Figures

Figure
Figure
A) Genome diagram indicating the location of structural (dark arrow) and nonstructural (shaded arrow) genes and the different regions (shaded boxes) used for phylogeny analysis. B) Phylogenetic trees based on deduced amino acid sequences of the spike protein S1 domain (a), the open reading frame (ORF)10' (b), and the N protein (c). Because of lack of the ORF10' coding region in Tor2, Tor2 could not be included for the tree in (b). GD01, human isolate from early phase of the outbreak in 2003; Tor2, human isolate from late phase of the outbreak in 2003; SZ3, civet isolate from March 2003; Rp3, bat isolate from Rhinolophus pearsoni, December 2004; Rf1, bat isolate from R. ferrumequinum, November 2004; Rm1, bat isolate from R. macrotis, November 2004; and HKU3–1, bat isolate from R. sinicus, February 2005. GenBank accession nos. appear next to isolate names.
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