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. 2007 Feb 9;315(5813):856-9.
doi: 10.1126/science.1133289.

VSports在线直播 - Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

Simon N Willis  1 , Jamie I Fletcher, Thomas Kaufmann, Mark F van Delft, Lin Chen, Peter E Czabotar, Helen Ierino, Erinna F Lee, W Douglas Fairlie, Philippe Bouillet, Andreas Strasser, Ruth M Kluck, Jerry M Adams, David C S Huang
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"VSports" Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

Simon N Willis (VSports app下载) et al. Science. .

Abstract

A central issue in the regulation of apoptosis by the Bcl-2 family is whether its BH3-only members initiate apoptosis by directly binding to the essential cell-death mediators Bax and Bak, or whether they can act indirectly, by engaging their pro-survival Bcl-2-like relatives. Contrary to the direct-activation model, we show that Bax and Bak can mediate apoptosis without discernable association with the putative BH3-only activators (Bim, Bid, and Puma), even in cells with no Bim or Bid and reduced Puma. Our results indicate that BH3-only proteins induce apoptosis at least primarily by engaging the multiple pro-survival relatives guarding Bax and Bak. VSports手机版.

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