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. 2006 Dec;133(24):4913-23.
doi: 10.1242/dev.02656. Epub 2006 Nov 15.

Novel binding partners of Ldb1 are required for haematopoietic development

Natalia Meier  1 , Sanja Krpic, Patrick Rodriguez, John Strouboulis, Maria Monti, Jeroen Krijgsveld, Martin Gering, Roger Patient, Arnd Hostert, Frank Grosveld
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"V体育2025版" Novel binding partners of Ldb1 are required for haematopoietic development

VSports手机版 - Natalia Meier et al. Development. 2006 Dec.

VSports注册入口 - Abstract

Ldb1, a ubiquitously expressed LIM domain binding protein, is essential in a number of tissues during development VSports手机版. It interacts with Gata1, Tal1, E2A and Lmo2 to form a transcription factor complex regulating late erythroid genes. We identify a number of novel Ldb1 interacting proteins in erythroleukaemic cells, in particular the repressor protein Eto-2 (and its family member Mtgr1), the cyclin-dependent kinase Cdk9, and the bridging factor Lmo4. MO-mediated knockdowns in zebrafish show these factors to be essential for definitive haematopoiesis. In accordance with the zebrafish results these factors are coexpressed in prehaematopoietic cells of the early mouse embryo, although we originally identified the complex in late erythroid cells. Based on the change in subcellullar localisation of Eto-2 we postulate that it plays a central role in the transition from the migration and expansion phase of the prehaematopoietic cells to the establishment of definitive haematopoietic stem cells. .

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