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. 2006 Nov 15;177(10):7346-54.
doi: 10.4049/jimmunol.177.10.7346.

"VSports手机版" Induction of tolerance to innocuous inhaled antigen relies on a CCR7-dependent dendritic cell-mediated antigen transport to the bronchial lymph node

Gabriele Hintzen  1 , Lars Ohl, Maria-Luisa del Rio, Jose-Ignacio Rodriguez-Barbosa, Oliver Pabst, Jessica R Kocks, Janet Krege, Svenja Hardtke, Reinhold Förster
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"VSports app下载" Induction of tolerance to innocuous inhaled antigen relies on a CCR7-dependent dendritic cell-mediated antigen transport to the bronchial lymph node

Gabriele Hintzen et al. J Immunol. .

VSports注册入口 - Abstract

Allergic airway diseases such as asthma are caused by a failure of the immune system to induce tolerance against environmental Ags. The underlying molecular and cellular mechanisms that initiate tolerance are only partly understood. In this study, we demonstrated that a CCR7-dependent migration of both CD103+ and CD103- lung dendritic cells (DC) to the bronchial lymph node (brLN) is indispensable for this process. Although inhaled Ag is amply present in the brLN of CCR7-deficient mice, T cells cannot be tolerized because of the impaired migration of Ag-carrying DC and subsequent transport of Ag from the lung to the draining lymph node. Consequently, the repeated inhalation of Ag protects wild-type but not CCR7-deficient mice from developing allergic airway diseases VSports手机版. Thus, the continuous DC-mediated transport of inhaled Ag to the brLN is critical for the induction of tolerance to innocuous Ags. .

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