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. 2006 Nov 15;177(10):6650-9.
doi: 10.4049/jimmunol.177.10.6650.

GATA-3 regulates the development and function of invariant NKT cells

Peter J Kim  1 , Sung-Yun Pai, Manfred Brigl, Gurdyal S Besra, Jenny Gumperz, I-Cheng Ho
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GATA-3 regulates the development and function of invariant NKT cells

Peter J Kim et al. J Immunol. .

V体育官网 - Abstract

Although invariant NKT (iNKT) cells participate in many aspects of immune responses, the molecular mechanisms regulating their development, maturation, and activation are still poorly understood. GATA-3 is a T cell-specific transcription factor that is also expressed in iNKT cells VSports手机版. The critical role of GATA-3 in conventional alphabeta T cells has been well documented, but whether GATA-3 also regulates the development and function of iNKT cells is unknown. In the present study, we report that deficiency of GATA-3 results in cell-intrinsic defects in the thymic development and peripheral maturation of murine iNKT cells. In addition, GATA-3 is also required for survival, activation, and effector functions of this unique population of T cells. Our data also reveal a previously unidentified peripheral maturation step that is GATA-3 dependent. .

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