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Comparative Study
. 2006 Nov;133(22):4427-38.
doi: 10.1242/dev.02644. Epub 2006 Oct 11.

V体育ios版 - Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis

Soline Estrach  1 , Carrie A Ambler, Cristina Lo Celso, Katsuto Hozumi, Fiona M Watt
Affiliations
Comparative Study

Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis

Soline Estrach et al. Development. 2006 Nov.

Abstract

The Wnt and Notch signalling pathways regulate hair follicle maintenance, but how they intersect is unknown. We show that Notch signalling is active in the hair follicle pre-cortex, a region of high Wnt activity, where commitment to hair lineages occurs. Deletion of jagged 1 (Jag1) results in inhibition of the hair growth cycle and conversion of hair follicles into cysts of cells undergoing interfollicular epidermal differentiation. Conversely, activation of Notch in adult epidermis triggers expansion of the base of the hair follicle, sebaceous gland enlargement and abnormal clumping of the follicles. In adult epidermis, the induction of new hair follicle formation by beta-catenin is prevented by blocking Notch signalling pharmacologically or through Jag1 deletion. Conversely, activation of both pathways accelerates growth and differentiation of ectopic follicles VSports手机版. beta-catenin stimulates Notch signalling by inducing Jag1 transcription. We conclude that the Notch pathway acts downstream of the Wnt/beta-catenin pathway to determine epidermal cell fate. .

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