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. 2006 Oct 1;66(19):9437-44.
doi: 10.1158/0008-5472.CAN-06-2074.

"VSports手机版" Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas

Inderpal Sarkaria  1 , Pornchai O-charoenrat, Simon G Talbot, Pabbathi G Reddy, Ivan Ngai, Ellie Maghami, Kepal N Patel, Benjamin Lee, Yoshihiro Yonekawa, Maria Dudas, Andrew Kaufman, Russell Ryan, Ronald Ghossein, Pulivarthi H Rao, Archontoula Stoffel, Y Ramanathan, Bhuvanesh Singh
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Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas

"VSports" Inderpal Sarkaria et al. Cancer Res. .

Abstract

Chromosomal amplification at 3q is common to multiple human cancers, but has a specific predilection for squamous cell carcinomas (SCC) of mucosal origin. We identified and characterized a novel oncogene, SCC-related oncogene (SCCRO), which is amplified along the 3q26. 3 region in human SCC. Amplification and overexpression of SCCRO in these tumors correlate with poor clinical outcome. The importance of SCCRO amplification in malignant transformation is established by the apoptotic response to short hairpin RNA against SCCRO, exclusively in cancer cell lines carrying SCCRO amplification VSports手机版. The oncogenic potential of SCCRO is underscored by its ability to transform fibroblasts (NIH-3T3 cells) in vitro and in vivo. We show that SCCRO regulates Gli1--a key regulator of the hedgehog (HH) pathway. Collectively, these data suggest that SCCRO is a novel component of the HH signaling pathway involved in the malignant transformation of squamous cell lineage. .

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