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. 2006 Oct 1;177(7):4311-21.
doi: 10.4049/jimmunol.177.7.4311.

VSports手机版 - T cell, Ig domain, mucin domain-2 gene-deficient mice reveal a novel mechanism for the regulation of Th2 immune responses and airway inflammation

Paul D Rennert  1 , Takaharu Ichimura, Irene D Sizing, Veronique Bailly, Zhifang Li, Rachel Rennard, Patricia McCoon, Lourdes Pablo, Steven Miklasz, Leticia Tarilonte, Joseph V Bonventre
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T cell, Ig domain, mucin domain-2 gene-deficient mice reveal a novel mechanism for the regulation of Th2 immune responses and airway inflammation

Paul D Rennert et al. J Immunol. .

"VSports在线直播" Abstract

The development of asthma and other atopic diseases is influenced by cytokines produced by Th2 effector T cells VSports手机版. How effector T cell responses are regulated once these cell populations are established remains unclear. The recently described T cell and airway phenotype regulator locus, containing the T cell, Ig domain, mucin domain (TIM) genes, is genetically associated with Th2 cytokine production and Th2-dependent immune responses. In this study, we report the phenotype of the TIM-2 gene-deficient mouse, and demonstrate exacerbated lung inflammation in an airway atopic response model. Immune responses in the TIM-2-deficient mouse reveal disregulated expression of Th2 cytokines, and adoptive transfer experiments show that the T cell compartment is responsible for the heightened inflammatory phenotype. These studies show that TIM-2 is a novel and critical regulator of effector T cell activity. .

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