"VSports app下载" Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The VSports app下载. gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. V体育官网.

. 2006 Sep;5(17):2005-11.
doi: 10.4161/cc.5.17.3194. Epub 2006 Sep 1.

DeltaNp63alpha overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse

Matthias Sommer  1 , Nina Poliak, Sunil Upadhyay, Edward Ratovitski, Barry D Nelkin, Lawrence A Donehower, David Sidransky
Affiliations

DeltaNp63alpha overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse

Matthias Sommer (VSports在线直播) et al. Cell Cycle. 2006 Sep.

Abstract

p63 is highly expressed in the skin and appears to be an early marker of keratinocyte differentiation. To examine the role of p63 in vivo, we generated transgenic mice that overexpress deltaNp63alpha in the skin. These mice exhibited an accelerated aging phenotype in the skin characterized by striking wound healing defects, decreased skin thickness, decreased subcutaneous fat tissue, hair loss, and decreased cell proliferation. The accelerated skin aging was accompanied by a dramatic decrease in longevity of the mice VSports手机版. We found that aging in deltaNp63alpha transgenic mice and other mouse models correlated with levels of Sirt1, a mammalian SIR2 orthologue thought to extend the lifespan in lower species. Moreover, increased deltaNp63alpha expression induced cellular senescence that was rescued by Sirt1. Our data suggest that deltaNp63alpha levels may affect aging in mammals, at least in part, through regulation of Sirt1. .

PubMed Disclaimer

Publication types

MeSH terms