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. 2006 Jul;25(1):93-104.
doi: 10.1016/j.immuni.2006.05.011.

Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk

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VSports注册入口 - Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk

Christine Broussard et al. Immunity. 2006 Jul.
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  • Immunity. 2006 Nov;25(5):849. Fleischecker, Christine [corrected to Fleischacker, Christine]

Abstract

Mutations affecting the Tec kinases Itk and Rlk decrease T cell receptor-induced Ca(2+) mobilization and Erk kinase activation and impair both positive and negative thymic selection VSports手机版. Itk(-/-) and Rlk(-/-)Itk(-/-) mice also have decreased CD4:8 T cell ratios, suggestive of altered CD4:8 lineage commitment. Nonetheless, we find that CD8 single-positive (SP) thymocytes and peripheral CD8(+) T cells in these mice do not resemble conventional CD8(+) T cells. Instead, these cells express memory markers, rapidly produce interferon-gamma, and can be selected on hematopoietically derived cells, similar to MHC class Ib-restricted "innate-type" lymphocytes. Itk deficiency also greatly increases the number of cells selected by MHC class Ib. Expression of a hypersensitive Erk2 mutant partially corrects the CD8(+) T cell phenotypes in Itk(-/-) mice, arguing that altered signaling permits development of this innate-type CD8(+) cell population. Our results suggest that Tec kinases differentially regulate development of conventional versus nonconventional lymphocytes. .

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