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. 2006 Jul 20;442(7100):299-302.
doi: 10.1038/nature04882.

Kruppel-like factor 2 regulates thymocyte and T-cell migration (V体育2025版)

Corey M Carlson  1 , Bart T Endrizzi, Jinghai Wu, Xiaojie Ding, Michael A Weinreich, Elizabeth R Walsh, Maqsood A Wani, Jerry B Lingrel, Kristin A Hogquist, Stephen C Jameson
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"V体育官网入口" Kruppel-like factor 2 regulates thymocyte and T-cell migration

Corey M Carlson et al. Nature. .

Abstract (V体育官网)

Mammalian Kruppel-like transcription factors are implicated in regulating terminal differentiation of several tissue types. Deficiency in Kruppel-like factor (KLF) 2 (also known as LKLF) leads to a massive loss of the peripheral T-cell pool, suggesting KLF2 regulates T-cell quiescence and survival. Here we show, however, that KLF2 is essential for T-cell trafficking. KLF2-deficient (Klf2-/-) thymocytes show impaired expression of several receptors required for thymocyte emigration and peripheral trafficking, including the sphingosine-1-phosphate (S1P) receptor S1P1, CD62L and beta7 integrin. Furthermore, KLF2 both binds and transactivates the promoter for S1P1--a receptor that is critical for thymocyte egress and recirculation through peripheral lymphoid organs. Our findings suggest that KLF2 serves to license mature T cells for trafficking from the thymus and recirculation through secondary lymphoid tissues VSports手机版. .

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