Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site VSports app下载. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. V体育官网.

. 2006 Jun 2;125(5):987-1001.
doi: 10.1016/j.cell.2006.03.046.

A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span

Maria K Lehtinen  1 , Zengqiang Yuan, Peter R Boag, Yue Yang, Judit Villén, Esther B E Becker, Sara DiBacco, Núria de la Iglesia, Steven Gygi, T Keith Blackwell, Azad Bonni
Affiliations
Free article

"VSports" A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span

"V体育平台登录" Maria K Lehtinen et al. Cell. .
Free article

"V体育2025版" Abstract

Oxidative stress influences cell survival and homeostasis, but the mechanisms underlying the biological effects of oxidative stress remain to be elucidated. Here, we demonstrate that the protein kinase MST1 mediates oxidative-stress-induced cell death in primary mammalian neurons by directly activating the FOXO transcription factors. MST1 phosphorylates FOXO proteins at a conserved site within the forkhead domain that disrupts their interaction with 14-3-3 proteins, promotes FOXO nuclear translocation, and thereby induces cell death in neurons. We also extend the MST-FOXO signaling link to nematodes. Knockdown of the C. elegans MST1 ortholog CST-1 shortens life span and accelerates tissue aging, while overexpression of cst-1 promotes life span and delays aging. The cst-1-induced life-span extension occurs in a daf-16-dependent manner. The identification of the FOXO transcription factors as major and evolutionarily conserved targets of MST1 suggests that MST kinases play important roles in diverse biological processes including cellular responses to oxidative stress and longevity. VSports手机版.

PubMed Disclaimer

V体育ios版 - Publication types

"VSports在线直播" MeSH terms