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Review
. 2006 Apr 7;22(1):5-13.
doi: 10.1016/j.molcel.2006.03.013.

"VSports注册入口" Making and breaking nucleic acids: two-Mg2+-ion catalysis and substrate specificity

Wei Yang  1 , Jae Young Lee, Marcin Nowotny
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Free article
Review

Making and breaking nucleic acids: two-Mg2+-ion catalysis and substrate specificity

Wei Yang et al. Mol Cell. .
Free article

Abstract

DNA and a large proportion of RNA are antiparallel duplexes composed of an unvarying phosphosugar backbone surrounding uniformly stacked and highly similar base pairs. How do the myriad of enzymes (including ribozymes) that perform catalysis on nucleic acids achieve exquisite structure or sequence specificity. In all DNA and RNA polymerases and many nucleases and transposases, two Mg2+ ions are jointly coordinated by the nucleic acid substrate and catalytic residues of the enzyme. Based on the exquisite sensitivity of Mg2+ ions to the ligand geometry and electrostatic environment, we propose that two-metal-ion catalysis greatly enhances substrate recognition and catalytic specificity. VSports手机版.

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