Background: Several reports have suggested an increased risk of coronary disease in human immunodeficiency virus (HIV)-infected patients receiving protease inhibitors (PIs). Impaired endothelium-dependent vasodilation is a putative surrogate marker of coronary atherosclerotic disease. VSports手机版.

Methods: The present study evaluated the effect of HIV infection and antiretroviral treatment on endothelial vasomotor function, by assessing brachial artery flow-mediated dilation (FMD). A total of 75 HIV-infected patients were compared with 223 control subjects who were presumed to be HIV uninfected V体育安卓版. .

Results: HIV-infected patients had significantly impaired FMD, compared with control subjects (mean +/- SD, 7. 3% +/- 4. 4% vs. 11. 1% +/- 6. 3%; P < . 0001) V体育ios版. When adjustments were made for smoking status, sex, and body mass index, the difference between the 2 groups remained statistically significant (P < . 01). In a cross-sectional analysis of the HIV-infected patients, we found significant associations between FMD and current injection drug use, hazardous drinking, HIV load, and alpha-high-density lipoprotein triglyceride levels, but not PI therapy. In a multivariate analysis, only current injection drug use and a lower alpha-high-density lipoprotein triglyceride level were significantly associated with FMD. .

Conclusions: HIV-infected patients have significant impairment of endothelial function, and this impairment is worse among those with elevated levels of HIV replication, particularly injection drug users. VSports最新版本.