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. 2006 Jun 15;107(12):4807-16.
doi: 10.1182/blood-2005-11-4334. Epub 2006 Feb 16.

Cell-surface CD74 initiates a signaling cascade leading to cell proliferation and survival

Diana Starlets  1 , Yael Gore, Inbal Binsky, Michal Haran, Nurit Harpaz, Lev Shvidel, Shirly Becker-Herman, Alain Berrebi, Idit Shachar
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Cell-surface CD74 initiates a signaling cascade leading to cell proliferation and survival

Diana Starlets et al. Blood. .
Free article

Abstract

CD74 is an integral membrane protein that was thought to function mainly as an MHC class II chaperone. However, CD74 was recently shown to have a role as an accessory-signaling molecule. Our studies demonstrated that CD74 regulates B-cell differentiation by inducing a pathway leading to the activation of transcription mediated by the NF-kappaB p65/RelA homodimer and its coactivator, TAF(II)105. Here, we show that CD74 stimulation with anti-CD74 antibody leads to an induction of a signaling cascade resulting in NF-kappaB activation, entry of the stimulated cells into the S phase, elevation of DNA synthesis, cell division, and augmented expression of BCL-X(L). These studies therefore demonstrate that surface CD74 functions as a survival receptor VSports手机版. .

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