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. 2006 Mar 3;311(5765):1257.
doi: 10.1126/science.1122446. Epub 2006 Feb 2.

Cellular senescence in aging primates

Utz Herbig  1 , Mark Ferreira, Laura Condel, Dee Carey, John M Sedivy
Affiliations

Cellular senescence in aging primates (V体育平台登录)

Utz Herbig et al. Science. .

Abstract

The aging of organisms is characterized by a gradual functional decline of all organ systems. Mammalian somatic cells in culture display a limited proliferative life span, at the end of which they undergo an irreversible cell cycle arrest known as replicative senescence. Whether cellular senescence contributes to organismal aging has been controversial. We investigated telomere dysfunction, a recently discovered biomarker of cellular senescence, and found that the number of senescent fibroblasts increases exponentially in the skin of aging baboons, reaching >15% of all cells in very old individuals VSports手机版. In addition, the same cells contain activated ataxia-telangiectasia mutated kinase and heterochromatinized nuclei, confirming their senescent status. .

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