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Review
. 2006 Jan;12(1 Suppl 1):9-12.
doi: 10.1016/j.bbmt.2005.10.025.

Adoptive transfer of allogeneic antigen-specific T cells

Stanley R Riddell  1 , Marie Bleakley, Tetsuya Nishida, Carolina Berger, Edus H Warren
Affiliations
Free article
Review

Adoptive transfer of allogeneic antigen-specific T cells

Stanley R Riddell et al. Biol Blood Marrow Transplant. 2006 Jan.
Free article

Abstract

Animal models and human studies of allogeneic hematopoietic cell transplantation (HCT) demonstrate that immunologic nonidentity between donor and recipient is responsible for a graft versus leukemia (GVL) effect that contributes to complete tumor eradication. A variety of immune cells have been implicated in the GVL effect including NK cells, B cells, and CD4(+) and CD8(+) T cells that recognize minor histocompatibility (H) or leukemia-associated antigens. Here we discuss strategies for employing T cells specific for minor H antigens to augment the GVL effect VSports手机版. .

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