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. 2006 Jan;50(1):148-55.
doi: 10.1128/AAC.50.1.148-155.2006.

In vitro activity of moxifloxacin against 923 anaerobes isolated from human intra-abdominal infections

Ellie J C Goldstein  1 , Diane M Citron, Yumi A Warren, Kerin L Tyrrell, C Vreni Merriam, Helen Fernandez
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In vitro activity of moxifloxacin against 923 anaerobes isolated from human intra-abdominal infections (VSports手机版)

Ellie J C Goldstein et al. Antimicrob Agents Chemother. 2006 Jan.

Abstract

The in vitro activity of moxifloxacin against 923 recent anaerobic isolates obtained from pretreatment cultures in patients with complicated intra-abdominal infections was studied using the CLSI M11-A-6 agar dilution method. Moxifloxacin was active against 87% (96 of 110) Bacteroides fragilis strains at < or = 1 microg/ml and 87% (79 of 90) B. thetaiotaomicron strains at < or = 2 microg/ml. Species variation was seen, with B. uniformis, B. vulgatus, Clostridium clostridioforme, and C. symbiosum being least susceptible and accounting for most of the resistant isolates; excluding the aforementioned four resistant species, 86% (303 of 363) of Bacteroides species isolates and 94% (417 of 450) of all other genera and species were susceptible to < or = 2 microg/ml of moxifloxacin. Overall, moxifloxacin was active against 763 of 923 (83%) of strains at < or = 2 microg/ml, supporting its use as a monotherapy for some community-acquired intra-abdominal infections VSports手机版. .

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