Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in VSports app下载. gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

Review
. 2005 Nov;6(11):827-37.
doi: 10.1038/nrm1743.

Coordinating ERK/MAPK signalling through scaffolds and inhibitors (V体育平台登录)

Walter Kolch  1
Affiliations
Review

Coordinating ERK/MAPK signalling through scaffolds and inhibitors

Walter Kolch. Nat Rev Mol Cell Biol. 2005 Nov.

Abstract

The pathway from Ras through Raf and MEK (MAPK and ERK kinase) to ERK/MAPK (extracellular signal-regulated kinase/mitogen-activated protein kinase) regulates many fundamental cellular processes. Recently, a number of scaffolding proteins and endogenous inhibitors have been identified, and their important roles in regulating signalling through this pathway are now emerging. Some scaffolds augment the signal flux, but also mediate crosstalk with other pathways; certain adaptors target MEK-ERK/MAPK complexes to subcellular localizations; others provide regulated inhibition. Computational modelling indicates that, together, these modulators can determine the dynamic biological behaviour of the pathway. VSports手机版.

PubMed Disclaimer

MeSH terms

LinkOut - more resources